| 計畫名稱 | 補助或委託機構 | 起訖日期 | 計畫內擔任工作 |
|---|---|---|---|
針對遺傳性視網膜失養症共通病理機制之外泌體治療平台A Mutation-Agnostic EV Platform for Targeting Common Mechanisms in Inherited Retinal Dystrophies |
佛教慈濟醫療財團法人台中慈濟醫院 (Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation.) |
2026/01/01 ~ 2026/12/31 | 主持人 (PI) |
CYP4V2-AAV在動物體內功效驗證In Vivo Efficacy Evaluation of CYP4V2-AAV in Animal Models of Inherited Retinal Degeneration |
生物技術開發中心 (Development Center for Biotechnology) |
2025/12/15 ~ 2026/12/15 | 主持人 (PI) |
DDX58基因變異與視網膜退化：從分子機制到潛在治療策略(114-2811-B-415-001-MY3)DDX58 Variants in Retinal Degeneration: From Molecular Mechanisms to Potential Therapeutic Strategies |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2025/08/01 ~ 2028/07/31 | 主持人 (PI) |
114年度「苦瓜品系潛力胜肽與外泌體之機能評估」委託專業服務案Functional Assessment of Potential Bioactive Peptides and Exosomes from Bitter Melon Cultivars |
農業部花蓮區農業改良場 (Hualien District Agricultural Research and Extension Station, Ministry of Agriculture) |
2025/01/17 ~ 2025/11/10 | 主持人 (PI) |
探究POMGnT1突變造成視網膜退化之致病機轉及發展治療策略(113-2811-B-415-003)Investigating the pathogenic mechanisms of POMGnT1-associated retinal dystrophy and developing therapeutic strategies |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2024/08/01 ~ 2025/07/31 | 主持人 (PI) |
113年度「苦瓜品系主效機能評估與外泌體製程研究」委託專業服務案Evaluation of Major Functional Activities and Exosome Manufacturing Processes of Bitter Melon Cultivars |
農業部花蓮區農業改良場 (Hualien District Agricultural Research and Extension Station, Ministry of Agriculture) |
2024/06/04 ~ 2024/11/10 | 主持人 (PI) |
CYP4V2基因藥物在視網膜的表現測試與在BCD疾病鼠治療後評估Evaluation of Retinal Expression of CYP4V2 Gene Therapy and Post-Treatment Assessment in a Mouse Model of Bietti Crystalline Dystrophy |
生物技術開發中心 (Development Center for Biotechnology) |
2024/04/01 ~ 2025/07/31 | 主持人 (PI) |
慈濟與中研院研究合作計畫未解之遺傳性視網膜退化症的基因體與功能性分析Genomic and Functional analysis of unsolved hereditary retinal dystrophies |
佛教慈濟醫療財團法人與慈濟大學 (Buddhist Tzu Chi Medical Foundation ＆ Tzu Chi University) |
2023/01/01 ~ 2025/12/31 | 主持人 (PI) |
基因性視網膜退化藥物開發與核酸藥物平台建置Drug Development for Genetic Retinal Degeneration and Establishment of a Nucleic Acid Therapeutics Platform |
生物技術開發中心 (Development Center for Biotechnology) |
2023/01/01 ~ 2024/12/31 | 主持人 (PI) |
苦瓜萃取物對視細胞損傷修復評估Assessment of the Protective and Reparative Effects of Bitter Melon Extracts on Retinal Cell Injury |
農業部花蓮區農業改良場 (Hualien District Agricultural Research and Extension Station, Ministry of Agriculture) |
2022/11/01 ~ 2024/03/31 | 主持人 (PI) |
慈濟與中研院研究合作計畫建立慈濟世代研究探討老化, 飲食, 微生物菌叢, 與疾病風險之交互作用Establishment of Tzu Chi Cohort Study to Explore the Interaction between Ageing, Diets, Microbiota, and Disease risk |
佛教慈濟醫療財團法人與慈濟大學 (Buddhist Tzu Chi Medical Foundation ＆ Tzu Chi University) |
2022/01/01 ~ 2025/12/31 | 主持人 (PI) |
新冠肺炎疫苗接種後血清學研究(TCU-B03)Evaluation of neutralizing antibody response to COVID-19 vaccination |
佛教慈濟慈善事業基金會與慈濟大學 (Buddhist Compassion Relief Tzu Chi Foundation & Tzu Chi University) |
2022/01/01 ~ 2024/12/31 | 主持人 (PI) |
探討缺血性視神經病視神經病變中泛素-蛋白酶系統與自噬機制間之交互作用(110-2314-B-320-003-MY3)Interplay between the ubiquitin-proteasome system and autophagy in ischemic optic neuropathy |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2021/08/01 ~ 2024/07/31 | 主持人 (PI) |
探討Nrf2在缺血性損傷中調控視神經結細胞存活的分子機轉(108-2314-B320-005-MY2)Investigating the molecular mechanism of Nrf2 signaling pathway in modulating retinal ganglion cell survival in ischemic injury |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2019/08/01 ~ 2021/07/31 | 主持人 (PI) |
慈濟與中研院研究合作計畫遺傳性視網膜退化疾病之基因體研究與功能分析(TCAS-107-02)Genomic and Functional analysis for hereditary retinal dystrophies |
佛教慈濟醫療財團法人與慈濟大學 (Buddhist Tzu Chi Medical Foundation ＆ Tzu Chi University) |
2018/10/01 ~ 2022/09/30 | 主持人 (PI) |
優秀年輕學者計畫 (Excellent Junior Research Investigator Grants)
使用oroxylin A 治療大白鼠視神經損傷模式的效用及分子機制探討(105-2628-B-320-002-MY3)Therapeutic efficacy and molecular mechanism of oroxylin A administration in a rat model of optic nerve crush |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2016/08/01 ~ 2019/07/31 | 主持人 (PI) |
使用P-selectin IgG chimera治療大白鼠前缺血性視神經病變模式的分子機轉探討(104-2314-B-320-002-)Therapeutic efficacy and molecular mechanism of P-selectin IgG chimera administration in a rat model of anterior ischemic optic neuropathy (rAION) |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2015/08/01 ~ 2016/07/31 | 主持人 (PI) |
大白鼠前缺血性視神經病變模式中使用 G-CSF及合併療法的效用及分子機轉探討(103-2314-B-303-007-MY3)Therapeutic efficacy and molecular mechanism of G-CSF administration and combined treatment in rAION |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2014/08/01 ~ 2017/07/31 | 共同主持人 (Co-PI) |
大白鼠前缺血性視神經病變模式中使用類固醇的效用及分子機轉探討(102-2314-B-303-008-)Therapeutic efficacy and molecular mechanism of steroid administration in rAION |
國家科學及技術委員會 (National Science and Technology Council, R.O.C) |
2013/08/01 ~ 2014/07/31 | 共同主持人 (Co-PI) |
嘧啶新合成基因 Cad 在調控視網膜細胞生長及分化之功能(102-2314-B-320-006-MY2)Investigating the function of a de novo pyrimidine biosynthesis gene, Cad, in cell proliferation and differentiation in retinogenesis |
國家科學及技術委員 (National Science and Technology Council, R.O.C) |
2013/08/01 ~ 2015/07/31 | 主持人 (PI) |
探討 peroxiredoxin 6 在糖尿病視網膜病變的分子病理機轉(101-2314-B-303-012-)Investigate the role of Peroxiredoxin 6 in the molecular and pathological mechanisms of diabetic retinopathy |
國家科學及技術委員 (National Science and Technology Council, R.O.C) |
2012/08/01 ~ 2013/07/31 | 主持人 (PI) |