期刊論文 / Publications

• Chien JY, Chan WH, Peng ML, Chau SF, Tsai HY, Lee SH, Chen YC, Cheang WM, Huang SP*. Nostoc commune Extract Attenuates Oxidative Stress and Neuroinflammation in Ischemic Optic Neuropathy Through PI3K/AKT/mTOR Signaling. Antioxidants. 2026, 15(5), 541. (SCIE, Impact Factor: 8.2, Ranking: 39/328, Biochemistry & Molecular Biology)
• Chien JY, Woon PY, Tsai HY, Peng ML, Lee SH, Chau SF, Chen YC, Cheang WM, Tsai CY, Huang SP*. Glycosylation-driven necroptosis in retinal degeneration: dual rescue by AAV8 gene therapy and RIPK1 inhibition. Cell Death Discovery. 2026 Apr 9;12(1):241. (SCIE, Impact Factor: 10.4, Ranking: 30/207, Cell Biology)
• Lin TY, Wang CY, Chen L, Huang SP*. Adaptive immune crosstalk and complement dysregulation in the aging retina. Tzu Chi Med J. 2026 Apr–Jun. 38(2):p 145-151. (ESCI, Impact Factor: 1.6, Ranking: 124/332, Medicine, General & Internal)
• Tsai CY, Weng CH, Teng CJ, Pan SY, Ho WT, Huang SP, Lu YA, Lin CY, Lin JF, Lin CH, Lin HJ, Wang IJ, Chou CC. Association Between Iron Overload and the Risk of Ocular Hypertension, Primary Open-Angle Glaucoma, and Normal-Tension Glaucoma. Transl Vis Sci Technol. 2025 Dec 1;14(12):13. (SCIE, Impact Factor: 2.6, Ranking: 26/99, Ophthalmology)
• Pan SY, Weng CH, Tien PT, Lu YA, Huang YH, Lin HJ, Cheng YD, Hsieh YW, Ho WT, Huang SP, Cho DY, Lin HJ, Wang IJ, Chou CC. Association Between Statin Use and Glaucoma Risk: A Population-Based Study. Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):7. (SCIE, Impact Factor: 4.7, Ranking: 9/99, Ophthalmology)
• Wang CY, Chen L, JY Chien, Huang SP*. Tailoring UPS-to-autophagy transition to restore RGC prosperity and functionality in a rodent traumatic optic neuropathy model. Experimental Eye Research. 2025 Sep. 258:110489. (SCIE, Impact Factor: 2.7, Ranking: 25/99, Ophthalmology)
• Wang CY, Chen L, Lin TY, Huang SP*. Systematic Identification of Candidate Genes for Inherited Retinal Disease Gene Therapy Integrating Worldwide IRD Cohort and Single-Cell Analysis. Journal of Ophthalmology. 2025 Jun. 2025:7014745. (SCIE, Impact Factor: 1.9, Ranking: 47/99, Ophthalmology)
• Lin TY, Wang CY, Chen L, Huang SP*. The ethnic disparity in the diagnostic yield of high-throughput next-generation sequencing in inherited retinal diseases: a systematic review and meta-analysis. Ophthalmic Genetics. 2025 Mar. 18:1-10. (SCIE, Impact Factor: 1.0, Ranking: 174/192 Genetics & Heredity)
• Peng ML, Chau SF, Chien JY, Woon PY, Chen YC, Cheang WM, Tsai HY, Huang SP*. Genetic Insights and Clinical Implications of NEU1 mutations in Sialidosis. Genes (Basel). 2025 Jan. 16 (2):151. (SCIE, Impact Factor: 2.8, Ranking:79/191, Genetics & Heredity)
• Kao HJ, Lin TY, Hsieh FJ, Chien JY, Yeh EC, Lin WJ, Chen YH, Ding KH, Yang Y, Chi SC, Tsai PH, Hsu CC, Hwang DK, Tsai HY, Peng ML, Lee SH, Chau SF, Chen CY, Cheang WM, Chen SJ, Kwok PY, Chiou SH, Lu MJ, Huang SP*. Highly efficient capture approach for the identification of diverse inherited retinal disorders. NPJ Genomic Medicine. 2024 Jan. 9(1):4. (SCIE, Impact Factor: 4.8, Ranking: 29/191, Genetics & Heredity)
• Chien JY, Ciou JW, Yen Y, Huang SP*. Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway. Biomed Pharmacother. 2023 Dec. 169:115861. (SCIE, Impact Factor: 7.5, Ranking: 19/352 Pharmacology& Pharmacy)
• Chien JY, Huang SP*. Gene therapy in hereditary retinal dystrophy. Tzu Chi Med J. 2022 Oct-Dec. 34(4):367-372. (ESCI, Impact Factor: 1.6, Ranking: 124/332 Medicine, General & Internal)
• Yang CC, Chien JY, Chou YY, Ciou JW, Huang SP*. The Effects of Lycium chinense, Cuscuta chinensis, Senna tora, Ophiopogon japonicus, and Dendrobium nobile Decoction on a Dry Eye Mouse Model. Medicina. 2022 Aug. 58(8), 1134. (SCIE, Impact Factor: 2.4, Ranking: 78/332 Medicine, General & Internal)
• Woon PY, Chien JY, Wang JH, Chou YY, Lin MC, Huang SP*. Prevalence and associated relating factors in patients with hereditary retinal dystrophy: a nationwide population-based study in Taiwan. BMJ Open. 2022 Apr. 12(4): e054111. (SCIE, Impact Factor: 2.3, Ranking: 84/332, MEDICINE, GENERAL & INTERNAL)
• Chou YY, Chien JY, Ciou JW, Huang SP*. The Protective Effects of n-Butylidenephthalide on Retinal Ganglion Cells during Ischemic Injury. International Journal of Molecular Sciences. 2022 Feb. 23(4), 2095. (SCIE, Impact Factor: 4.9, Ranking: 72/319, Biochemistry & Molecular Biology)
• Chien JY, Chou YY, Ciou JW, Liu FY, Huang SP*. The Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy. Antioxidants. 2021, 10(9), 1466. (SCI, impact factor: 6.312, 60/297, Biochemistry & Molecular Biology)
• Chien JY, Lin SF, Chou YY, Huang CYF, Huang SP*. Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy. Antioxidants. 2021, 10(6), 902. (SCI, impact factor:5.014, 10/139, Food science & Technology)
• Kapupara K, Huang TL, Wen YT, Huang SP*, Tsai RK.Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy. Exp Eye Res. 2018 Dec 15;181:105-111. doi: 10.1016/j.exer.2018.12.007; (SCI, impact factor: 3.332, 10/59, Ophthalmology)
• Kim HS, Huang SP, Lee EJ, Craft CM.Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol. 2018;1074:281-287. doi: 10.1007/978-3-319-75402-4_34. (SCI, impact factor: 1.76 ; 38/85, Biology)
• Kapupara K, Wen YT, Tsai RK, Huang SP*. Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury. Cell Death& Disease. 2017, 8 (11), e3172; doi:10.1038/cddis.2017.566 (SCI, impact factor:5.965; 39/190, Cell Biology)
• Lin SF, Chien JY, Kapupara K, Huang CY, Huang SP*. Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model. PLos One. 2017, 12(6):e0178584 (SCI, impact factor:3.057; 11/63 Multidisciplinary sciences)
• Wen YT, Huang TL, Huang SP, Chang CH, Tsai RK. Early applications of granulocyte colony-stimulating factor (G-CSF) can stabilize the blood-optic-nerve barrier and ameliorate inflammation in a rat model of anterior ischemic optic neuropathy (rAION). Disease Models and Mechanisms. 2016, 9(10):1193-1202 (SCI, impact factor:4.316; 7/75, Pathology)
• Huang SP, Fang KT, Chang CH, Huang TL, Wen YT, Tsai RK. Autocrine Protective Mechanisms of Human Granulocyte Colony-stimulating Factor (G-CSF) on Retinal Ganglion cells after Optic Nerve Crush. Exp Eye Res. 2016,143:132-140 (SCI, impact factor: 2.709, 14/57, Ophthalmology)
• Chien JY, Sheu JH, Wen ZH, Tsai RK, Huang SP*. Neuroprotective effect of 4-(Phenylsulfanyl)butan-2-one on optic nerve crush model in rats. Exp Eye Res. 2016,143:148-157(SCI, impact factor: 2.709, 14/57, Ophthalmology)
• Huang SP*, Chien JY, Tsai RK. Ethamtubol induces impaired autophagic flux and apoptosis in the retina. Disease Models and Mechanisms. 2015, 8, 977-987(Impact factor: 4.973; Ranking:7/75, Pathology)
• Huang TL, Huang SP, Chang CH, Lin KH, Chang SW, Tsai RK. Protective effects of systemic treatment with methylprednisolone in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION). Exp Eye Res. 2015, 131:69-76 (Impact factor: 3.017; Ranking: 9/58, Ophthalmology)
• Chen PY, Ho YR, Wu MJ, Huang SP, Chen PK, Tai MH, Ho CT, Yen JH. Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells. Food & Function. 2015, 6(1):286-95 (Impact factor:2.907, Ranking: 16/123, Food Science & Technology)
• Huang SP, Tsai RK. The efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy (rAION). Journal of Neural Regeneration Research. 2014; 9(16):1502-5 (Impact factor: 0.234, Ranking:245/252, Neuroscience)
• Huang TL, Huang SP, Chang CH, Lin KH, Sheu MM, Tsai RK. Protective effects of cerebrolysin in a rat model of optic nerve crush. Kaohsiung J Med Sci. 2014 Jul; 30(7): 331-6 (Impact factor: 0.805; Ranking: 102/124, Medicine, Research & Experimental)
• Lin HZ, Huang SP, Tsai RK. Treatment of Leber’s Hereditary Optic Neuropathy. Neuro-Ophthalmology Japan, 2014, 31:89-94
• Huang TL*, Huang SP*, Chang CH, Lin KH, Sheu MM, Tsai RK. Factors influencing the retrograde labeling of retinal ganglion cells with floro-gold in an animal optic nerve crush model. Ophthalmic Res. 2014 18:51(4): 173-178 (co-first author)(Impact factor: 1.376; Ranking:35/58, Ophthalmology)
• Lai YH*, Huang SP*, Chen SP, Hu PS, Lin SF, Sheu MM, Wang HZ, Tsai RK. A Novel Gene Mutation in Family with X-linked Retinoschisis. J Formos Med Assoc. 2014 Feb 13. (co-first Author) (Impact factor: 1.968; Ranking :54/153, Medicine, General & Internal)
• Chang CH, Huang TL, Huang SP, Tsai RK. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Experimental Eye Research. 2014 Jan, 118:109-16. (Impact factor: 3.017; Ranking: 9/58, Ophthalmology)
• Huang TL, Huang SP, Lin KH, Tsai RK. Management of Non-Arteritic Anterior Ischemic Optic neuropathy. Neuro-Ophthalmology Japan, 2013, 30:425-429
• Huang SP, Tsai RK. Regenerative Medicine in Optic Neuropathy. Neuro-Ophthalmology Japan, 2013, 30:327-331
• Huang SP, Tsai RK. Mechanisms of Retinal Ganglion Cell Death in Optic Neuropathies. Neuro-Ophthalmology Japan, 2013, 30:217-224
• Huang SP, Craft CM. Potential Cellular Functions of N-Ethylmalemide Sensitive Factor in the Photoreceptor. Adv Exp Med Biol. 2012;723:791-7. In Retinal Degenerative Diseases: Mechanisms and Experimental Therapy. (Impact factor:2.012; Ranking: 24/85, Biology)
• Huang SP, Brown BM, Craft CM. Visual arrestin1 Acts as a modulator for N-ethylmaleimide sensitive factor in the photoreceptor synapse. Journal of Neuroscience 2010; 30:9381-9391. (Selected for Faculty of 1000 Biology)(Impact Factor: 6.747; Ranking:24/252, Neuroscience)
• Huang SP, Palla S, Ruzychi P, Varma A, Harter T, Reddy GB, Petrash JM. Aldo-Keto reductase in the eyes. Journal of Ophthalmology,vol. 2010, Article ID 521204, 6 pages, 2010. doi:10.1155/2010/521204. (Impact factor: 1.935; Ranking: 25/58, Ophthalmology)
• Chen CP, Lee YJ, Chiu ST, Shyu WC, Lee MY, Huang SP, Li H. The application of stem cells in the treatment of ischemic diseases. Histol Histopathol. 2006 Nov; 21(11):1209-16. Review.
• Huang SP, Lin PK, Liu JH, Khor CN, Lee YJ. Intraocular gene transfer of ciliary neurotrophic factor rescues photoreceptor degeneration in RCS rats. J Biomed Sci. 2004 Jan-Feb;II(I):37-48.
• Huang SP, Lin PK, Li AF, Chung YM, Yang CS, Liu JH. Multiple evanescent white dots syndrome--- A report of 12 cases The official Journal of the ophthalmologic society of the Republic of China 39(3): 573-577, Nov 2000

專利 / Patents and Patent Applications

• 黃舜平, 簡嘉瑩 Use of a RIP1 inhibitor or a MLKL inhibitor for treating or preventing hereditary retinal dystrophy.R1P1抑制劑或MLKL抑制劑用於治療或預防遺傳性視網膜失養症的用途. 2024/02/11. 中華民國發明專利第 I832531號
• Chou YY, Chien JY, Ciou JW, Huang SP. Methods for treating or preventing ischemic optic neuropathy. 2023/11/28. US patent No. 11,826,340 B1.
• 周鈺曜, 簡嘉瑩, 邱智韋, 黃舜平 Pharmaceutical use of N-Butylidenephthalide. 正丁烯基苯酞的醫藥用途. 2022/10/11. 中華民國發明專利第 I781073號
• 黃舜平 Use of a composition for treating, reducing, preventing deterioration or improving visual function after optic neuropathy.一種醫藥組合物用於製備治療、減少、預防或改善視神經病變後的視覺功 能退化之藥物的用途方法.2021/05/01. 中華民國發明專利第 I726172號
• 黃舜平,蔡榮坤. Method for providing ocular neuroprotection or for preventing, treating or alleviating the effects of, an ocular disease associated with retinal ganglion cell death. 用於提供眼部神經保護或用於預防、治療與視網膜神經節細胞死亡相關的眼部疾病或減輕其影響的方法. 2020/04/21. 中華民國發明專利第 I691508號
• Huang SP, Sheu JH, Wen ZH, Tsai RK. Method of treating or preventing the visual function loss by using 4-(phenylsulfanyl)butane-2-one (4-PSB-2). 2018/03/06, US patent No. US9907763 B2.
• 黃舜平, 許志宏,溫志宏, 蔡榮坤. Use a compound for preparing pharmaceutical composition for neuroprotective effect on optic nerve. 一種化合物用於製備治療視神經之醫藥組合物的用途. 2017/05/11. 中華民國發明專利第 I581790號

研討會論文 / Conference Paper

• Chien JY, Huang SP. (2025): Exploring the Neuroprotective Effects of Bitter Gourd Extract in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology & Visual Science. May 2025, Vol.66 (8), 1221.
• Huang SP, Chien JY, Woon PY, Tsai HY, Chau SF, Chen CY, Cheang WM, Peng ML. (2025): Mechanistic Elucidation of POMGnT1 Mutation-Induced Retinal Degeneration and Preclinical Therapeutic Strategies. Investigative Ophthalmology & Visual Science. May 2025, Vol.66 (8), 2488.
• Zhan WX, Chien JY, Huang SP. (2024): The protective effects of Nostoc Commune on retinal ganglion cells in an experimental ischemic optic neuropathy murine model. 2024 39th SNP and 24th SFRR-Taiwan (第39屆天然藥物研討會/第24屆台灣自由基學術研討會聯合會), PP-61, 15880356.
• Chu CY, Chien JY, Chyuan JH, Wu DR, Huang SP. (2024): The protective effects of Momordica charantia L. var.abbreviata Ser on retinal ganglion cells during ischemic injury. 2024 39th SNP and 24th SFRR-Taiwan (第39屆天然藥物研討會/第24屆台灣自由基學術研討會聯合會), PP-60, 15880355.
• Chien JY, Huang SP. (2024): Neuroprotective Effects of RIPA-56 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology & Visual Science. May 2024, Vol.65 (7), 3945.
• Huang SP, Chien JY. (2024): The effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy. Investigative Ophthalmology & Visual Science. May 2024, Vol.65 (7), 1239.
• Chien JY, Huang SP. (2023): POMGNT1 deficiency causes retinal degeneration through triggering RIP-1 dependent necroptotic cell death in a murine model. Investigative Ophthalmology & Visual Science. April 2023, Vol.64 (8), 749.
• Huang SP, Kao HJ, Lin TY, Chien JY, Kwok PY, Lu Jade MY, Chiou SH. (2023): Highly efficient capture approach for the identification of diverse inherited retinal disorders. Investigative Ophthalmology & Visual Science. May 2023, Vol.64 (8), 4647.
• Huang SP, Chien JY. (2020): Neuroprotective Effects of Novel Compound 056 in optic nerve degeneration model. Investigative Ophthalmology & Visual Science. May 2020, Vol.61 (7), 2487.
• Huang SP, Chien JY, Chou YY. (2019): The effects of Nrf2 activator in a rodent model of anterior ischemic optic neuropathy (rAION). Investigative Ophthalmology & Visual Science. April 2019, Vol.60 (9), 5745.
• Huang SP, Chien JY, Kapupara K, Chou YY, Tsai RK. (2018): Neuroprotective effects of oroxylin A in a rodent model of nonarteritic anterior ischemic optic neuropathy. Investigative Ophthalmology & Visual Science. April 2018, Vol.59 (9), 2499.
• Kapupara K, Huang SP, (2017). Neuroprotective Effect of P-selectin-IgG Chimera in Rodent Model of Anterior Ischemic Optic Neuropathy (rAION) CM096 32th Joint Annual Conference of Biomedical Science.
• Huang SP, (2017): Neuroprotective effect of P-selectin Immunoglobin G chimera administration in a rat optic nerve crush model. ARVO Asia, Brisbane, Australia.
• Huang SP, Lin SF, Tsai RK. (2013): Ethambutol-induced autophagy deregulation and cytotoxic effects in retinal ganglion cells. Investigative Ophthalmology & Visual Science. June 2013, Vol.54, 1812.
• Huang SP, Lin SF, Tsai RK. (2012): The Molecular Mechanism of Cytotoxic Effects of Ethambutol in Retinal Ganglion Cells. 19^th International Neuro-Ophthalmology Society Meeting. (Best Poster Presentation Award)
• Yetemian RM, Huang SP, Brown BM, Wu GS, Craft CM. (2011): Susceptibility Modifiers Contribute to Phenotype Variability in Mouse Arrestin1 Knockout Cone Dystrophy. Invest Ophthalmol Vis Sci 2011;52: E-Abstract 78.
• Huang SP, Brown BM, Craft CM. (2010): Visual Arrestin 1 is Essential for Photoreceptor Synaptic Regulation. the XIVth International symposium of Retinal Degeneration P134. (RD2010 Young Investigator Award)
• Huang SP, Brown BM, Craft CM. (2010): Visual Arrestin 1 is Essential for Photoreceptor Synaptic Regulation. Invest Ophthalmol Vis Sci 2010;51: E-Abstract 4134.
• Huang SP, Brown BM, Craft CM. (2009): N-Ethylmaleimide Acts as a Functional Partner for Visual Arrestin1 in the Photoreceptors Invest Ophthalmol Vis Sci 2009;50: E-Abstract 5430.
• Petrash, JM, Huang SP. (2007): Elevation of Aldose Reductase in the Diabetic Eye. Invest Ophthalmol Vis Sci 2007;48: E-Abstract 2029.
• Huang SP., Khor CN., Lee SM., Li H., and Lee YJ. (2004): GCSF rescues retinal cell apoptosis in transient optic ischemia in the rat. Annual Meeting of the Association for Research in Vision and Ophthalmology 2004: 3284/B919
• Huang SP, Lin PK, Lin TN, Lee YJ, Ke CY, Chang Y, Hsu WM, Liu JH. Adenovirally expressed Ciliary Neurotrophic Factor Rescues Photoreceptor cells in RCS rats. Investigative Ophthalmology & Visual Science 42(4):S348, March 15,2001 (2001 ARVO Annual Meeting Travel Grant Award)

專書 / Books

• Huang SP(2010) Exploring Alternative Roles of Visual Arrestin 1 in Photoreceptor Synaptic Regulation and Deciphering the Molecular Pathway of Retinal Degeneration using Mouse Knockout Technology. Ph.D. Thesis. Genetic, Molecular and Cellular Biology, University of Southern California.

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